|
Symbol Name ID |
Tnfrsf13b
tumor necrosis factor receptor superfamily, member 13b MGI:1889411 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Decreased circulating IgA level |
Decreased circulating IgG level |
Decreased circulating total IgM |
Partial absence of specific antibody response to unconjugated pneumococcus vaccine |
Impaired T cell function |
Abnormal T cell count |
Recurrent sinusitis |
Conjunctivitis |
Lymphadenopathy |
Follicular hyperplasia |
Splenomegaly |
Recurrent otitis media |
Recurrent pneumonia |
Autoimmunity |
Combined immunodeficiency |
Recurrent bacterial infections |
Recurrent bronchitis |
Meningitis |
| Disease(s) Associated with TNFRSF13B | ||||||||||||||||||
| common variable immunodeficiency 2 |
| Mouse Phenotypes | immune system phenotype |
increased B cell proliferation |
enlarged spleen |
increased spleen weight |
abnormal class switch recombination |
increased transitional stage B cell number |
increased mature B cell number |
increased follicular B cell number |
increased marginal zone B cell number |
increased B cell number |
abnormal spleen morphology |
abnormal spleen primary B follicle morphology |
increased spleen germinal center size |
abnormal spleen periarteriolar lymphoid sheath morphology |
increased spleen white pulp amount |
abnormal B cell activation |
abnormal immunoglobulin level |
decreased IgA level |
decreased IgE level |
decreased IgG1 level |
increased IgG1 level |
decreased IgM level |
abnormal Peyer's patch follicle morphology |
abnormal lymph node primary follicle morphology |
enlarged lymph nodes |
increased anti-nuclear antigen antibody level |
increased anti-double stranded DNA antibody level |
liver inflammation |
kidney inflammation |
glomerulonephritis |
|
| Availability | Mouse Genotype | ||||||||||||||||||||||||||||||
| Tnfrsf13btm1Cmac/Tnfrsf13btm1Cmac | * | ||||||||||||||||||||||||||||||
| Tnfrsf13btm1Rjb/Tnfrsf13btm1Rjb | |||||||||||||||||||||||||||||||
| Tnfrsf13btm1Vmd/Tnfrsf13btm1Vmd | |||||||||||||||||||||||||||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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